Oggi il fisico Clarbruno Vedruccio e la moglie Dott.ssa Carla Ricci - il primo come inventore del Bioscanner TRIMprob, la seconda come attiva collaboratrice del progetto - hanno informato i loro contatti della pubblicazione di uno studio (realizzato presso il Camargo Hospital, Cancer Center di San Paolo del Brasile - grande struttura di riferimento per tutta l'America Latina) sull'utilizzo del TRIMprob per la diagnosi del tumore prostatico (PCa) a confronto con la risonanza magnetica multiparametrica (MRI).
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Int Braz J Urol. 2016 Sep 20. doi: 10.1590/S1677-5538.IBJU.2015.0714. [Epub ahead of print]
(1)Núcleo de Urologia, Departamento de Cirurgia Pélvica, AC Camargo Cancer Center, SP, Brasil.
OBJECTIVES: To evaluate the predictive value of TRIMprob test to detect prostate cancer (PCa) in patients referred to prostate biopsy (PB).
MATERIAL AND METHODS: Patients with PSA <10ng/mL and rectal exam without findings suggestive of prostate cancer were selected for TRIMprob evaluation. Exam was performed by a single operator through transperineal approach. Patients admitted for the study were submitted to TRIMprob and multiparametric magnetic resonance (mpMRI) and posteriorly to PB.
RESULTS: In total, 77 patients were included. TRIMprob showed evidences of PCa in 25 (32.5%) and was negative in 52 patients (67.5%). The rate of detection of prostate cancer at biopsy was higher in patients with positive TRIMprob (16/25; 64.0%) than in patients with negative TRIMprob (11/52; 21.1%; p<0.001). Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of TRIMprob were respectively 61.5%, 82.0%, 64.0%, 80.3% and 74.0%. ROC curve showed the following areas under the curve values for TRIMprob, mpMRI and combination of TRIMprob + mpMRI: 0.706; 0.662 and 0.741 respectively. At combined analysis, when both TRIM¬prob and mpMRI were negative for prostate cancer, accuracy was 96.3% or only 1 in 27 PB was positive (3.7%).
CONCLUSIONS: Trimprob had similar predictive value for PCa in patients submitted to PB as mpMRI. Combined TRIMprob and mpMRI showed higher accuracy than when performed singly.
Copyright® by the International Brazilian Journal of Urology.
[PubMed - as supplied by publisher]